生命学院揭示细胞程序性坏死调控新机制

ON2019-08-12CATEGORY科研进展

7月31日,bodog体育生命科学与技术学院王华翌课题组和陆珺霞课题组合作在学术期刊Cell Death & Differentiationbodog体育(《细胞死亡与分化》)在线发表学术论文“RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif”。

xibaochengxuxinghuaisi(necroptosis)shiyizhongyouxibaowaiyinziruzhongliuhuaisiyinzi(tumor necrosis factor, tnf)youdaodexibaosiwangfangshi,zaitineicanyudiaokongbingyuantimianyi、qiguansunshangdengshenglibingliguocheng。xibaochengxuxinghuaisixinhaozaixibaoneidezhuandao,youkezhuanbianweidianfenyangxianweijiegoujibeichengweihuaisixiaoti(necrosomes)dedanbaifuhewufuze。huaisixiaotizhong,shoutixianghuzuoyongdanbaijimei3 (receptor-interacting protein kinase 3,rip3)jiqishangyoudiaokongdanbaisuogongyoudeyizhongbeichengweishoutixianghuzuoyongdanbaitongxingxianghuzuoyongjixu(rip homotypic interaction motif, rhim)dejiegouyuzhijiecanyudianfenyangxianweijiegoudexingcheng。huaisixiaotidianfenyangxianweijiegoudexingchengshihuaisixiaotichengshuherip3jimeidejihuosuobixude,shixibaochengxuxinghuaisitongludebiyaobuzhou,danqijutijizhishangweiqueding。

zaigaixianggongzuozhong,yanjiurenyuantongguoyuanzilixianweijingdeguance,faxiandanduderip3hem45dianfenyangjiegoujuyoubutongdexianweijianjujifangshi,zaijiegoushangxianghujiekang。rip3hem45xingchengyizhixingdianfenyangfuhewuhou,xianweijiandejujichuxianwenluan。yinciyanjiurenyuantuiduanm45tongguoyizhirip3danbaixianweijiandejinyibujuji,congeryizhixibaochengxuxinghuaisixinhaodezhuandao。liyongtubiansaomiao,tamenjiandingchuxinxingrip3tubianti,gaitubiantizaihuaisiyoudaohoukeyuyeshengxingrip3yiyangxingchengdianfenyangxianweijiegou,danshitabunengtongguoxianweijiandejujijinyibuzuzhuangchengdadedianfenyangjuhewu。xiangyingdi,zheigerip3tubiantizaiganyinghuaisixinhaohoubunengbeijihuo,congerzuzhilexibaochengxuxinghuaisidefasheng。

bodog体育juci,yanjiurenyuantichurip3dianfenyangdanbaidexingchengdiaokongxibaochengxuxinghuaisixinhaochuandidexinjizhi: rip3tongguoqirhimxingchengdianfenyangxianweidanbaishixibaochengxuxinghuaisidebiyaotiaojian,danbuzhijieyoudaorip3dezijihuo。rip3suoxingchengdedianfenyangxianweihaixutongguoyouxudexianweijianjuji,zuizhongzuzhuangchengdadedianfenyangjuhewucainengjiedaorip3jimeidezijihuohexibaochengxuxinghuaisidefasheng。zheiyibuzhoukeyitongguoyuyizhixingdem45-rhimjieheerzuduan,zheiyeshim45yizhixibaochengxuxinghuaisideneizaijizhi。

bodog体育zheixianggongzuoshoucizhengminglerhimdianfenyangxianweijiandeyouxupailieduixibaochengxuxinghuaisixinhaozhuandaodezhongyaoxing,yeshidiyiciyongshilizhengmingdianfenyangxianweijiandepailiehejujizhijieyingxiangdianfenyangdanbaidegongneng。youyushoutixianghuzuoyongdanbairhimdesanweidanbaijiegouyujingdiandeaercihaimozhengxiangguandianfenyangdanbaiamyloid-β (aβ)-40dejiegouxiangsi,tishiruaβdengbinglixiangguandianfenyangdanbaidexianweijianyouxujiehe,kenengyouzhuyudianfenyangdanbaidechenjihejibingdejinzhan。yincizheixianggongzuozaigainianshangweidianfenyangdanbaixiangguanjibingdebaxiangzhiliaotigongxinsilu。

wanghuayiketizuboshiyanjiushenghuhonghelujunxiaketizuboshihouwuxialianweibenlunwengongtongdiyizuozhe,wanghuayijiaoshouhelujunxiajiaoshouweigongtongtongxunzuozhe,shanghaikejidaxueweidiyiwanchengdanwei。benyanjiudedaoleshanghaikejidaxueshengmingkexueyujishuxueyuanfenziyingxiangpingtai、fenzixibaopingtai、shengwudianjingpingtaihewuzhixueyuanfenxiyiqizhongxindedalizhichi。gaiyanjiugongzuodedaoleguojiazirankexuejijinheshanghaikejidaxueshengmingkexueyujishuxueyuankeyanqidongxiangmuzizhu。

wenzhanglianjie:

bodog体育rhimdianfenyangdanbaiyilaiderip3jihuohem45yizhideyuanlimoshitu

congzuodaoyou: wanghuayijiaoshou、wanghuayiketizuboshiyanjiushenghuhong、lujunxiaketizuboshihouwuxialian