beijingshijian8yue5ri，bodogtiyushengmingxueyuanwanghaopengketizulianhezhongkeyuanfenzixibaokexuezhuoyuechuangxinzhongxinxuchenqishiyanshi、fudandaxuefushuyanerbihoukeyiyuanwuhaitaoketizu，zai《mianyi》（immunity）shangyifengmianwenzhangdexingshifabiaoletiwei“chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy”（juyouchijiukangzhongliuxiaoguodexinxingkexunhuanqianhexingkangyuanshouti）deyanjiulunwen，tichuleyizhongxinxingde“kexunhuancar”shejifangan，xianzhuditigaolecar-txibaozaitineidechixuhuoxinghekangzhongliuxiaoguo，weifangzhicar-tzhiliaohoudezhongliufufatigonglexincelve。
car-tliaofashitongguozaihuanzhezishentxibaoshangbiaodaqianhexingkangyuanshouti（chimeric antigen receptor, car），shiqinenggoushibiebingshashangaizhengxibaodeyizhongzhongliumianyiliaofa。car-tliaofayizaiduozhongexingblinbazhongliuzhongzhanxianchulingrenzhumudeliaoxiao，bingqieliangkuancar-tchanpinyu2017nianchenggonghuopishangshi。ranerzuoweiyizhongxindeliaofa，car-tzhiliaoyeyouqijuxianxing。linchuangshujuxianshi，gaoda30%-50%jingcar-tzhiliaodebingrenhuichuxianzhongliufufadexianxiang，bingqiedaduoshuhuanzhehuizaiqizhiliaohouyinianneichuxianfufa。daozhihuanzhezhongliufufadeyuanyinyouduozhong，qizhongcar-txibaodetineichixuhuoxing（in vivo persistence），jicar-txibaozaihuanzhetineicunhuoshijiandezhangduan，shiyigejuedingxingdeyinsu。zaizhenduijixingbaixuebingyijimanxingbaixuebingdelinchuangyanjiuzhongyizhifaxian，car-tliaofadeliaoxiaoyucar-txibaozaibingrentineidechixuhuoxingchengzhengxiangguanxing。yinci，ruhetigaocar-txibaodechixuhuoxingchengweidangxiadeyanjiuredian。
zaigaixiangyanjiuzhong，yanjiurenyuanshoucizhengminglecarshoutizaijiehezhongliukangyuanhouhuifashengfansuhuaxiushijirongmeitijiedaodecardejiangjie，congerdaozhixibaobiaomiancarshoutishuipingxianzhu xiadiao。yanjiurenyuanjinyibubacarbaoneiduandefansuhuaweidianlaiansuanktubianweijingansuanr（carkr），zuduanlecardefansuhuaxiushijirongmeitidejiangjie，yizhilecardexiadiaoguocheng。gaizaohoudecarxiangjiaoyuchuantongdecarnenggoufuyutxibaogengqiangdekangzhongliuxiaoguohechixuhuoxing，jinyibudejizhixingtansuofaxian，gaizaohoudecarzaitxibaozhongxunhuan（recycling），bingzaijihuohoufujizaibaoneineiti（endosome）zhong，qibaoneiduan4-1bbjiegouyurengranjiehezhexinhaochuandifenzitraf2，zaibaoneizhixingxinhaochuandigongneng，yinerzengqiangle4-1bbxiayouxinhao，cujinletxibaodedaixiezhongbiancheng（tigaoxianlitideshengchengjiyanghualinsuanhuadaixie）jizhongyangxingjiyitxibaodefenhua。yanjiutuanduijiangzheizhongquanxindeshejimingmingweikexunhuancar（recyclable car）。zheixiejieguoweihouxukexunhuancardelinchuangyanzhengtigonglejianshidejichu。
bodog体育zaigaixiangmuzhong，shanghaikejidaxueweidiyiwanchengdanwei。shanghaikejidaxueboshiyanjiushengliwentao、qiushizhenjifudandaxuechenjianboshiweilunwengongtongdiyizuozhe。wanghaopengyanjiuyuan、xuchenqiyanjiuyuanhewuhaitaojiaoshouweigongtongtongxunzuozhe。shanghaikejidaxuefangaofengketizu、nanfangkejidaxuetianruijunketizu、beijingdaxueweipingketizucanyuyanjiu。benyanjiudedaoshanghaikejidaxueshengmingxueyuanfenzixibaopingtai、fenziyingxiangpingtai、shengwuzhipupingtaiheguojiadanbaizhikexuezhongxin（shanghai）dongwusheshidejishuzhichi，binghuodeguojiazirankexuejijin、guojiazhongdianyanfajihuadejingfeizhichi。
kexunhuancardeliaoxiaohejizhi: zuotu: kexunhuancar-txibaogaoxiaodiqingchutineizhongliu。youtu: zhongliukangyuandejiehedaozhicarshoutidefansuhuaxiushi，fansuhuadecarshoutibeiyunshudaorongmeitijinxingjiangjie；kexunhuancarshoutibuzaibeirongmeitijiangjie，ershijujizai“neiti”zhongjinxingxinhaozhuandao，bingqiebeishusonghuidaocar-txibaobiaomian，cujinlecar-txibaokangaihuoxing。
lunwenlianjie:
