生命学院王皞鹏课题组与合作者开发新型CAR-T疗法

ON2019-08-06CATEGORY科研进展

beijingshijian8yue5ri,bodogtiyushengmingxueyuanwanghaopengketizulianhezhongkeyuanfenzixibaokexuezhuoyuechuangxinzhongxinxuchenqishiyanshi、fudandaxuefushuyanerbihoukeyiyuanwuhaitaoketizu,zai《mianyi》(immunity)shangyifengmianwenzhangdexingshifabiaoletiwei“chimeric antigen receptor designed to prevent ubiquitination and downregulation showed durable antitumor efficacy”(juyouchijiukangzhongliuxiaoguodexinxingkexunhuanqianhexingkangyuanshouti)deyanjiulunwen,tichuleyizhongxinxingde“kexunhuancar”shejifangan,xianzhuditigaolecar-txibaozaitineidechixuhuoxinghekangzhongliuxiaoguo,weifangzhicar-tzhiliaohoudezhongliufufatigonglexincelve。

car-tliaofashitongguozaihuanzhezishentxibaoshangbiaodaqianhexingkangyuanshouti(chimeric antigen receptor, car),shiqinenggoushibiebingshashangaizhengxibaodeyizhongzhongliumianyiliaofa。car-tliaofayizaiduozhongexingblinbazhongliuzhongzhanxianchulingrenzhumudeliaoxiao,bingqieliangkuancar-tchanpinyu2017nianchenggonghuopishangshi。ranerzuoweiyizhongxindeliaofa,car-tzhiliaoyeyouqijuxianxing。linchuangshujuxianshi,gaoda30%-50%jingcar-tzhiliaodebingrenhuichuxianzhongliufufadexianxiang,bingqiedaduoshuhuanzhehuizaiqizhiliaohouyinianneichuxianfufa。daozhihuanzhezhongliufufadeyuanyinyouduozhong,qizhongcar-txibaodetineichixuhuoxing(in vivo persistence),jicar-txibaozaihuanzhetineicunhuoshijiandezhangduan,shiyigejuedingxingdeyinsu。zaizhenduijixingbaixuebingyijimanxingbaixuebingdelinchuangyanjiuzhongyizhifaxian,car-tliaofadeliaoxiaoyucar-txibaozaibingrentineidechixuhuoxingchengzhengxiangguanxing。yinci,ruhetigaocar-txibaodechixuhuoxingchengweidangxiadeyanjiuredian。

zaigaixiangyanjiuzhong,yanjiurenyuanshoucizhengminglecarshoutizaijiehezhongliukangyuanhouhuifashengfansuhuaxiushijirongmeitijiedaodecardejiangjie,congerdaozhixibaobiaomiancarshoutishuipingxianzhu xiadiao。yanjiurenyuanjinyibubacarbaoneiduandefansuhuaweidianlaiansuanktubianweijingansuanr(carkr),zuduanlecardefansuhuaxiushijirongmeitidejiangjie,yizhilecardexiadiaoguocheng。gaizaohoudecarxiangjiaoyuchuantongdecarnenggoufuyutxibaogengqiangdekangzhongliuxiaoguohechixuhuoxing,jinyibudejizhixingtansuofaxian,gaizaohoudecarzaitxibaozhongxunhuan(recycling),bingzaijihuohoufujizaibaoneineiti(endosome)zhong,qibaoneiduan4-1bbjiegouyurengranjiehezhexinhaochuandifenzitraf2,zaibaoneizhixingxinhaochuandigongneng,yinerzengqiangle4-1bbxiayouxinhao,cujinletxibaodedaixiezhongbiancheng(tigaoxianlitideshengchengjiyanghualinsuanhuadaixie)jizhongyangxingjiyitxibaodefenhua。yanjiutuanduijiangzheizhongquanxindeshejimingmingweikexunhuancar(recyclable car)。zheixiejieguoweihouxukexunhuancardelinchuangyanzhengtigonglejianshidejichu。

bodog体育zaigaixiangmuzhong,shanghaikejidaxueweidiyiwanchengdanwei。shanghaikejidaxueboshiyanjiushengliwentao、qiushizhenjifudandaxuechenjianboshiweilunwengongtongdiyizuozhe。wanghaopengyanjiuyuan、xuchenqiyanjiuyuanhewuhaitaojiaoshouweigongtongtongxunzuozhe。shanghaikejidaxuefangaofengketizu、nanfangkejidaxuetianruijunketizu、beijingdaxueweipingketizucanyuyanjiu。benyanjiudedaoshanghaikejidaxueshengmingxueyuanfenzixibaopingtai、fenziyingxiangpingtai、shengwuzhipupingtaiheguojiadanbaizhikexuezhongxin(shanghai)dongwusheshidejishuzhichi,binghuodeguojiazirankexuejijin、guojiazhongdianyanfajihuadejingfeizhichi。

kexunhuancardeliaoxiaohejizhi: zuotu: kexunhuancar-txibaogaoxiaodiqingchutineizhongliu。youtu: zhongliukangyuandejiehedaozhicarshoutidefansuhuaxiushi,fansuhuadecarshoutibeiyunshudaorongmeitijinxingjiangjie;kexunhuancarshoutibuzaibeirongmeitijiangjie,ershijujizai“neiti”zhongjinxingxinhaozhuandao,bingqiebeishusonghuidaocar-txibaobiaomian,cujinlecar-txibaokangaihuoxing。

lunwenlianjie: