上科大免化所团队发现小鼠胚胎早期发育的重要调控机制

ON2019-07-24CATEGORY科研进展

bodogtiyumianyihuaxueyanjiusuotepinjiaoshou、shengmingxueyuanchuangshiyuanzhanglinhaifanyanjiutuanduitongguoyunyongduozhongjishushouduan,faxianlejingdianrnajiehedanbai——pumiliozaixiaoshuzaoqifayuzhongdezhongyaoyiyi,bingjieshilefanyishuipingdediaojieduipeitaiganxibaoziwogengxinhefenhuadediaokongzuoyong。jinri,gaiyanjiuchengguoyi”pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis”weitifabiaozaiguojizhimingqikan《meiguokexueyuankan》(proceedings of the national academy of science, pnas)shang。

zaidangjinpeitaiganxibaodeyanjiuzhong,duoshuyanjiuchengguojizhongzaidnazhuanludiaokonglingyu,erzhanjudiaojiebiligenggao、caokonggengweijingxidezhuanluhoushuipingdediaokongquejiaoshaoyouyanjiuchuji。ganxibaodegengxinhefenhuashiyigejiweijingmiyouxudeguocheng,gegecengmiandediaokongdouzaifayuguochengzhongzhanjuzheduteerzhongyaodediwei。qizhong,fanyijifanyihoushuipingdediaojiezuoweizuijiejinshengwuxuegongnengdebuzhou,xiandeyouweizhongyao。pumiliodanbaishiyileirnajiehedanbai,duibabiaohesuanyouzhejingxidexulieshibiehejiehediaokong。zaiburudongwuzhong,pumiliodanbaijiazuyoulianggechengyuan: pum1 yupum2。linhaifanyanjiutuanduizaiciqiandeyanjiuzhong,chanminglepumiliodanbaijiazuzaiburudongwushengzhixitongfayuyushenjingganxibaofenhuadengfangmiandegongneng。raner,pumiliodanbaizaipeitaifayuzhongdegongneng,yijifayuguochengzhonglianggetongyuanjiyindejutigongnengrengbumingque。linhaifanjiaoshouzaimianhuasuodeyanjiutuanduiyutazaiyeludaxueganxibaozhongxindeyanjiutuanduihezuo,congxiaoshuqiaochumoxingchufa,fenlibingjianlilexiaoshupeitaiganxibaoxi,duipum1hepum2jiyindeshengwuxuegongnenghefenzijizhijinxingleyanjiu。

yanjiujieguoxianshi,pumiliodanbaijiazuzaixiaoshupeitaidezaoqifayuzhongbukehuoque,duipeitaidecunhuoqizhezhiguanzhongyaodezuoyong。danyuchuantongrenzhibutongdeshi,peitaiganxibaoyanjiubiaoming,pum1yupum2zaiganxibaoweichihefenhuazhonggongnengxiangfanerhubu(tu1)。pum1tongguojiangdiduonengxingxiangguanjiyindebiaodacongercujinpeitaiganxibaodefenhua。yuqibutongdeshi,pum2zezhizaiweichipeitaiganxibaodeziwogengxin,yizhiganxibaoguozaofenhua。zheiyifaxiandiyicijieshilepumiliotongyuanjiyinzaipeitaiganxibaozhongdebutonggongneng,duitongyuandanbaijinxinglegengweijingxidefenlei,youliyujianglaiteyibadiandeshaixuanheyanjiu。

zuoweirnajiehedanbai,pum1yupum2duirnayeqizhezhiguanzhongyaodediaojiezuoyong。benyanjiuliyonghetangtitupujishu,duipum1yupum2danbaizaifanyidiaojieguochengzhongdegongnengjinxingleshenrudefenxi。yanjiufaxian,pumiliodanbaikeduishangqiangejiyindexinshirnazaifanyishijinxingdiaokong,jineryingxiangqibiaodaheshengwuxuegongneng。jinyibufenxibiaoming,zaizheixiebeidiaokongdernazhong,bujinjinyoubeipumiliozhijiejiehebingdiaokongderna,yecunzaizhedaliangdefeizhijiejiehederna,zheiyushizhepumiliodanbaikenengyuqitarnajiehedanbaiyouxianghuzuoyong,bingcanyubutongdegongnengtonglu。benyanjiuweijinyibujieshipumiliodanbaigongnengtigonglejichu,weipeitaiganxibaozhongrnadiaojiedelantuhuizhitigonglegengduodesucai,yekuitanlepeitaizaoqifayulirnashijiedebingshanyijiao。

bodog体育shangkedamianhuasuoboshiyanjiushengyangyiyingheyeludaxueyixueboshiyanjiushengkatherine e. uyhaziweigaiyanjiulunwengongtongdiyizuozhe,linhaifanjiaoshouweigailunwendetongxunzuozhe。shangkedamianhuasuoheyeludaxueganxibaozhongxinweigongtongwanchengdanwei。shangkedamianhuasuojishengmingkexueyujishuxueyuandeduogejishupingtaiweibenketideshunlibodogtiyutigonglezhongyaodeyiqizhichihejishuzhichi。

tu1: pum1hepum2zaipeitaiganxibaoyijipeitaizaoqifayuzhongdegongnengdeshiyitu

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